Towards Detection of Cyberbullying in Hinglish Code Mixed Data

Covid-19 eruption and lockdown situation have increased the usages of online platforms which have impacted the users. Cyberbullying is one of the negative outcomes of using social media platforms which leads to mental and physical distress. This study proposes a machine learning-based approach for the detection of cyberbullying in Hinglish text. We use the Hinglish Code-Mixed Corpus, which consists of over 6,000 tweets, for our experiments. We use various machine learning algorithms, including Logistic regression (LR), Multinomial Naive Bayes (MNB), Support vector machine (SVM), Random Forest (RF), to train our models. We evaluate the performance of the models using standard evaluation metrics such as precision, recall, and F1-score. Our experiments show that the LR with Term Frequency-Inverse Document Frequency (TFIDF) outperforms the other models, achieving 92% accuracy. Our study demonstrates that machine learning models can be effective for cyberbullying detection in Hinglish text, and the proposed approach can help identify and prevent cyberbullying on social media platforms. © 2023 Bharati Vidyapeeth, New Delhi.

The pathogenesis of COVID-19: Hypercoagulation and D-dimer in thrombotic complications

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) caused a new coronavirus disease (COVID-19), which is highly contagious and its pathogenesis has not been fully elucidated. In COVID-19, the inflammation and blood coagulation systems are excessively activated. SARS-CoV-2 damages endothelial cells and pneumocytes, which leads to disruption of hemostasis in SARS. Thromboembolism is the main cause of mortality in patients with COVID-19. Clots, including pulmonary embolism (PE) and deep vein thrombosis (DVT), ranging from minor to fatal complications of the SARS-CoV-2 infection are known. Individuals with pre-existing diseases are more susceptible to the development of blood clots and poor outcomes. High levels of circulating cytokines and D-dimer (DD) are influential biomarkers of poor outcomes in COVID-19. The latter occurs as a result of hyperfibrinolysis and hypercoagulation. Plasmin is a key player in fibrinolysis and is involved in the cleavage of many viral envelope proteins, including SARS-CoV. Due to this function penetration of viruses into the host cell occurs. In addition, plasmin is involved in the pathophysiology of acute respiratory distress syndrome (ARDS) in SARS and promotes the secretion of cytokines, such as IL-6 and TNF, from activated macrophages. The focus of existing treatment to alleviate fibrinolysis in patients with COVID-19 is the use of systemic fibrinolytic therapy given thrombotic pathology in severe forms of COVID-19 which may lead to death. However, fibrinolytic therapy may be harmful in the advanced stages of COVID-19, when the status of disseminated intravascular coagulation (DIC) changes from suppressed fibrinolysis to its enhancement during the progression of the disease. This narrative review aims to elucidate the pathogenesis of COVID-19, which will further help in precise diagnosis and treatment. Take-home message: The COVID-19 virus disrupts haemostasis and thromboembolism by over activating the inflammation and blood coagulation systems. High levels of cytokines and D-dimer are indicators of pre-existing diseases and blood clots. Systemic fibrinolytic treatment can reduce severe fibrinolysis in COVID-19, which is caused by plasmin. In the late stages of DIC, when fibrinolysis increases, it may be dangerous. To improve therapy and results, understanding COVID-19 pathogenicity is critical. © 2023 by the authors.

Assessment of Stress, Anxiety, and Depression Levels Among COVID-19 Positive Patients Admitted in Rural Tertiary Care Hospital

Objective: The aim of the present study was to investigate the psychiatric distress, including stress, anxiety, and depression levels, among COVID-19 positive patients who were admitted between 01 July 2020 to 31 August 2020 to the COVID-19 isolation ward of the Uttar Pradesh University of Medical Sciences, Saifai, Etawah India. Participants included 100 patients, with 55 males and 45 females. The majority of admitted patients (81%) were illiterate. Out of 100 patients, 83 were married, 16 were unmarried, and only 1 was a widow. Method(s): Levels of anxiety, depression, and stress level were noted in admitted patients using Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire (PHQ-9) depression assessment, and Perceived Stress Scale 4 (PSS-4) assessment techniques, respectively. Result(s): Patient Health Questionnaire (PHQ-9) depression assessment results showed minimal, mild, and moderate depression in 9, 25, and 66 patients, respectively, with a 10.6 median score of PHQ-9. Mild, moderate, and severe anxiety (GAD-7 score) was present in 22, 28, and 50 of the patients surveyed. The mean Perceived Stress Scale 4 (PSS-4) was also analyzed, and it reported 6.1 values. The results of the study demonstrated that the patients had a high label of psychiatric distress, but still, admitted patients believe that they will come out from this pandemic condition. Conclusion(s): Although patients claimed psychiatric distress and mental health illness, they still denied the requirement of any mental health professionals to minimize stress levels and were satisfied with the medical facilities available in a hospital located in a rural area.Copyright © 2022 Bentham Science Publishers.

Effect of an Ayurvedic Intervention (Ayush-64) as a Stand-Alone Treatment in Mild to Moderate COVID-19: An Exploratory Prospective Single-Arm Clinical Trial

An Ayurvedic polyherbal formulation (Ayush-64) was repurposed for use in mild to moderate COVID-19 cases based on the supportive evidence obtained from a pilot study on its effect on Influenza like illness (ILI) and molecular docking study which revealed that several compounds isolated from Ayush-64 demonstrated antiviral activity. The study aims at evaluating the effect of an Ayurvedic intervention (Ayush-64) in mild to moderate COVID-19 patients. A prospective single arm, pilot study in mild to moderate COVID-19 patients. The study was conducted at Chaudhary Brahm Prakash Ayurved Charak Sansthan (CBPACS), New Delhi, India. A total of 37 COVID-19 participants confirmed through RT-PCR were included in the study. The proportion of participants with negative SARS-CoV-2 on nasal or throat swab in a 2-day consecutive real-time RT-PCR test was evaluated as the secondary outcome. In the study, 86.1% of participants demonstrated clinical recovery with 14 days of use of Ayush-64 as stand-alone treatment without any other conventional medicines, out of which 75% clinically recovered within 8 days. Further, 69.4% of participants turned negative by the 15th day, out of which 50% became COVID-19 negative on the 8th day. No AE/ ADR was observed during the study. Ayush-64 may significantly facilitate clinical improvement in terms of duration for clinical recovery and attaining negative conversion in mild to moderate COVID-19 cases.

Traditional medicinal plants as promising source of immunomodulator against covid-19

Outbreak of novel corona virus (Covid-19) or Severe Acute Respiratory Syndrome corona virus 2 (SARS CoV-2) was noticed in China at the end of 2019 and has now become one of the major global health threat. Although, Covid-19 virus imposes detrimental effects to all groups of persons irrespective of their age, sex, race and body physic. Immuno-compromised people are reported to be severely affected in comparison to immunocompetent persons, suggesting immunity as a major player against SARS CoV-2. Despite of great efforts and intensive researches carried all over the world, so far there are no clinically approved vaccines or specific therapeutic drugs available for Covid-19. In this regard, different traditional medicinal plants, which are vast reservoir of bioactive compounds with broad therapeutic and immunomodulatory properties, have been emerged as boon to combat with Covid-19. Along with pharmacological properties and easily availability, safety paradigm of ethnomedicinal plants makes them highly preferable immediate remedy to enhance immunity and compete with novel corona virus. Use of traditional Indian spices has been also realized as effective and safer strategy in order to boost immunity and deal with highly terrible current Covid-19 situation. Hence, there is need to boost the efficacy of the traditionally used plant based immunomodulators against Covid-19 pandemic incorporating modern biotechnological and pharmacological tools so as to enhance bioavailability and practical applicability. The present article deals with general feature of SARS CoV-2 along with recent reports on efficacy of traditional medicinal plants as well as Indian spices as an effective immunomodulator for Covid-19. © 2020, Editorial board of Journal of Experimental Biology and Agricultural Sciences. All rights reserved.

Dental practice guidelines in the precariousness of COVID-19: A review

The rapid spread of novel corona virus declared as a pandemic by the World Health Organisation has created a sense of panic across the globe, nor sparing the Dentistry in the process. The mode of transmission of the virus is through infected secretions such as saliva and respiratory secretions or their respiratory droplets, which are expelled when an infected person coughs, sneezes, talks or sings, has created the need to control the contact spread of the infectious virus between humans. This de-manded a responsible emergence of medical as well as Dental care to handle the situation of the pandemic with utmost care. The need for proper guidelines from time to time has been a key to the emerging safe dental practices amongst dental profes-sionals. Focusing not only on the emergencies but also on the routine procedures is a major challenge at the present. The best delivery of dental treatment can only be given when proper protocols are being followed. A crucial aspect being the protection of the spread of the disease from an asymptomatic patient should be considered. This review has been articulated considering the dire need of the hour to protect the dental professionals, the auxiliaries as well as the patient from the infectious spread of the disease. It encourages them to know the various methods of the protective aspects of dentistry amidst this pandemic and its importance in clinical practice. Also, additional aspects of precautions while screening the patient, while performing various procedures and the disinfection of the operatory has been discussed. © IJCRR.